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  February 22, 2012  

Classification of Herbicides According to Site of Action

Farmers, advisors and researchers should know which herbicides are best suited to combat specific resistant weeds. To support the use of herbicides suitable for resistance management the enclosed classification of herbicides is proposed.

The herbicides are classified alphabetically according to their target sites, stites of action, similarity of induced symptoms or chemical classes.

If different herbicide groups share the same site of action only one letter is used. In the case of photosynthesis inhibitors subclasses C1, C2 and C3 indicate different binding behaviour at the binding protein D1 or different classes. Bleaching can be caused by different ways. Accordingly subgroups F1, F2 and F3 are introduced. Growth inhibition can be induced by herbicides from subgroups K1, K2 and K3. Herbicides with unknown sites of action are classified in group Z as "unknown" until they can be grouped exactly.

Classification of Herbicides

In order to avoid confusion with I and O categories J and Q are omitted. New herbicides will be classified in the respective groups or in new groups (R, S, T...).

Since the system was in part developed in co-operation with the "Weed Science Society of America (WSSA)" new herbicides should be categorised jointly by HRAC and WSSA. 

For reference the numerical system of the WSSA is listed, too.

The aim of HRAC is to create a uniform classification of herbicide sites of action in as many countries as possible.

Such a classification system can be useful for many instances but there are cases where weeds exhibit multiple resistance across many of the groups listed and in these cases the key may be of limited value.

The system itself is not based on resistance risk assessment but can be used by the farmer or advisor as a tool to choose herbicides in different sites of action groups, so that mixtures or rotations of active ingredients can be planned.

For a figure of the chemical groups involved each HRAC Group, click on the letter in the table below. A synoptic graphic of the HRAC groups is also available.

The WSSA and HRAC systems differ in minor ways.  Herbicides in italics are listed on the HRAC classification system but are not listed on the WSSA classification.

January 2005

HRAC: Herbicide classification

HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

A

Inhibition of acetyl
CoA carboxylase
(ACCase)
Aryloxyphenoxy-propionate
‘FOPs’
 
 
 
 
clodinafop-propargyl
cyhalofop-butyl
diclofop-methyl
fenoxaprop-P-ethyl
fluazifop-P-butyl
haloxyfop-R-methyl
propaquizafop
quizalofop-P-ethyl

1

    Cyclohexanedione
‘DIMs’
alloxydim
butroxydim
clethodim
cycloxydim
profoxydim
sethoxydim
tepraloxydin
tralkoxydim
 
    Phenylpyrazoline
‘DEN’
pinoxaden  

B

Inhibition of acetolactate synthase ALS
(acetohydroxyacid synthase AHAS)
Sulfonylurea amidosulfuron
azimsulfuron
bensulfuron-methyl
chlorimuron-ethyl
chlorsulfuron
cinosulfuron
cyclosulfamuron
ethametsulfuron-methyl
ethoxysulfuron
flazasulfuron
flupyrsulfuron-methyl-Na
foramsulfuron
halosulfuron-methyl
imazosulfuron
iodosulfuron
mesosulfuron
metsulfuron-methyl
nicosulfuron
oxasulfuron
primisulfuron-methyl
prosulfuron
pyrazosulfuron-ethyl
rimsulfuron
sulfometuron-methyl
sulfosulfuron
thifensulfuron-methyl
triasulfuron
tribenuron-methyl
trifloxysulfuron
triflusulfuron-methyl
tritosulfuron

2

    Imidazolinone imazapic
imazamethabenz-methyl
imazamox
imazapyr
imazaquin
imazethapyr
 
    Triazolopyrimidine cloransulam-methyl
diclosulam
florasulam
flumetsulam
metosulam
penoxsulam
 
    Pyrimidinyl(thio)benzoate bispyribac-Na
pyribenzoxim
pyriftalid
pyrithiobac-Na
pyriminobac-methyl
 
    Sulfonylaminocarbonyl-triazolinone flucarbazone-Na
propoxycarbazone-Na
 
HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

C1

Inhibition of photosynthesis at
photosystem II
Triazine ametryne
atrazine
cyanazine
desmetryne
dimethametryne
prometon
prometryne
propazine
simazine
simetryne
terbumeton
terbuthylazine
terbutryne
trietazine

5

    Triazinone hexazinone
metamitron
metribuzin
 
    Triazolinone amicarbazone  
    Uracil bromacil
lenacil
terbacil
 
    Pyridazinone pyrazon = chloridazon  
    Phenyl-carbamate desmedipham
phenmedipham
 

C2

Inhibition of photosynthesis at
photosystem II
Urea chlorobromuron
chlorotoluron
chloroxuron
dimefuron
diuron
ethidimuron
fenuron

fluometuron (see F3)
isoproturon
isouron
linuron
methabenzthiazuron
metobromuron
metoxuron
monolinuron
neburon
siduron
tebuthiuron

7

    Amide propanil
pentanochlor
 

C3

Inhibition of photosynthesis at
photosystem II
Nitrile bromofenoxim
bromoxynil
ioxynil

6

    Benzothiadiazinone bentazon  
    Phenyl-pyridazine pyridate
pyridafol
 

D

Photosystem-I-electron diversion Bipyridylium diquat
paraquat

22

HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

E

Inhibition of protoporphyrinogen oxidase
(PPO)
Diphenylether acifluorfen-Na
bifenox
chlomethoxyfen
fluoroglycofen-ethyl
fomesafen
halosafen
lactofen
oxyfluorfen

14

    Phenylpyrazole fluazolate
pyraflufen-ethyl
 
    N-phenylphthalimide cinidon-ethyl
flumioxazin
flumiclorac-pentyl
 
    Thiadiazole fluthiacet-methyl
thidiazimin
 
    Oxadiazole oxadiazon
oxadiargyl
 
    Triazolinone azafenidin
carfentrazone-ethyl
sulfentrazone
 
    Oxazolidinedione pentoxazone  
    Pyrimidindione benzfendizone
butafenacil
 
    Other pyraclonil
profluazol

flufenpyr-ethyl
 

F1

Bleaching:
Inhibition of carotenoid biosynthesis at the phytoene desaturase step (PDS)
Pyridazinone norflurazon

12

    Pyridinecarboxamide diflufenican
picolinafen
 
    Other beflubutamid
fluridone
flurochloridone
flurtamone
 

F2

Bleaching:
Inhibition of 4-hydroxyphenyl-pyruvate-dioxygenase (4-HPPD)
Triketone mesotrione
sulcotrione

27

    Isoxazole isoxachlortole
isoxaflutole
 
    Pyrazole benzofenap
pyrazolynate
pyrazoxyfen
 
    Other benzobicyclon  

F3

Bleaching:
Inhibition of carotenoid biosynthesis (unknown target)
Triazole amitrole
(in vivo inhibition of
lycopene cyclase)

11

    Isoxazolidinone clomazone

13

    Urea fluometuron (see C2)  
    Diphenylether aclonifen  

G

Inhibition of EPSP synthase Glycine glyphosate
sulfosate

9

H

Inhibition of glutamine synthetase Phosphinic acid glufosinate-ammonium
bialaphos = bilanaphos

10

HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

I

Inhibition of DHP (dihydropteroate) synthase Carbamate asulam

18

K1

Microtubule assembly inhibition Dinitroaniline benefin = benfluralin
butralin
dinitramine

ethalfluralin
oryzalin
pendimethalin
trifluralin

3

    Phosphoroamidate amiprophos-methyl
butamiphos
 
    Pyridine dithiopyr
thiazopyr
 
    Benzamide propyzamide = pronamide
tebutam
 
    Benzoic acid DCPA = chlorthal-dimethyl

3

K2

Inhibition of mitosis / microtubule organisation Carbamate chlorpropham
propham

carbetamide

23

K3

Inhibition of VLCFAs ( see Remarks)
(Inhibition of cell division)
Chloroacetamide acetochlor
alachlor
butachlor

15

      dimethachlor
dimethanamid
metazachlor
metolachlor
pethoxamid
 
      pretilachlor
propachlor
propisochlor
thenylchlor
 
    Acetamide diphenamid
napropamide
naproanilide
 
    Oxyacetamide flufenacet
mefenacet
 
    Tetrazolinone fentrazamide  
    Other anilofos
cafenstrole
piperophos
 

L

Inhibition of cell wall (cellulose) synthesis Nitrile dichlobenil
chlorthiamid

20

    Benzamide isoxaben

21

    Triazolocarboxamide flupoxam  
    Quinoline carboxylic acid quinclorac (for  monocots)
(also group O)

26

HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

M

Uncoupling (Membrane disruption) Dinitrophenol DNOC
dinoseb

dinoterb

24

N

Inhibition of lipid synthesis - not ACCase inhibition Thiocarbamate butylate
cycloate
dimepiperate
EPTC
esprocarb
molinate
orbencarb
pebulate
prosulfocarb
thiobencarb = benthiocarb
tiocarbazil
triallate
vernolate

8

    Phosphorodithioate bensulide  
    Benzofuran benfuresate
ethofumesate
 
    Chloro-Carbonic-acid TCA
dalapon
flupropanate

26

O

Action like indole acetic acid
(synthetic auxins)
Phenoxy-carboxylic-acid clomeprop
2,4-D
2,4-DB
dichlorprop = 2,4-DP
MCPA
MCPB
mecoprop = MCPP = CMPP

4

    Benzoic acid chloramben
dicamba
TBA
 
    Pyridine carboxylic acid clopyralid
fluroxypyr
picloram
triclopyr
 
    Quinoline carboxylic acid quinclorac
(also group L)
quinmerac
 
    Other benazolin-ethyl  

P

Inhibition of auxin transport Phthalamate
Semicarbazone
naptalam
diflufenzopyr-Na

19

HRAC Group Site of Action Chemical Family Active Ingredient WSSA Group

R

.... ... ...  

S

... ... ...  

.

... ... ...  

Z

Unknown
Note:  While the site of action of herbicides in Group Z is unknown it is likely that they differ in site of action between themselves and from other groups.
Arylaminopropionic acid Flamprop-M-methyl /-isopropyl

25

    Pyrazolium difenzoquat

26

    Organoarsenical DSMA
MSMA

17

    Other bromobutide
(chloro)-flurenol

 

      cinmethylin  
      cumyluron  
      dazomet  
      dymron = daimuron
methyl-dimuron=
methyl-dymron
etobenzanid

fosamine
indanofan
metam
oxaziclomefone
oleic acid
 
      pelargonic acid
pyributicarb
 

Remarks:
According to information and comments following herbicides are classified in the January 2005
version in HRAC (WSSA) groups:

B (2): cancelled: #9; #9; procarbazone
Approved ISO name: propoxycarbazone
 
E (14): cancelled: pyrazogyl
Approved name: pyraclonil

Information
HRAC
Dr. Hubert Menne
Bayer CropScience AG
Industriepark Höchst, H872
D-65926 Frankfurt / Main
Phone: +49 69 305 14486
Fax: +49 69 305 7342
E-mail: hubert.menne@bayercropscience.com


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